Diane E Merry Selected Research

X-Linked Bulbo-Spinal Atrophy

1/2021	Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
10/2019	Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease.
1/2019	Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy.
1/2017	The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms.
12/2015	Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.
12/2015	Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy.
5/2015	Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis.
2/2015	Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.
3/2014	Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
2/2013	Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

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Diane E Merry Research Topics

Disease

24	X-Linked Bulbo-Spinal Atrophy 01/2021 - 01/2002
10	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2015 - 03/2002
5	Muscular Atrophy (Muscle Atrophy) 12/2015 - 05/2004
3	Huntington Disease (Huntington's Disease) 01/2021 - 08/2002
2	Neuromuscular Diseases (Neuromuscular Disease) 10/2019 - 01/2019
2	Spinal Diseases (Disease, Spinal) 05/2015 - 05/2004
2	Motor Neuron Disease (Primary Lateral Sclerosis) 07/2005 - 05/2004
1	Neoplasms (Cancer) 03/2015
1	Prostatic Neoplasms (Prostate Cancer) 03/2015
1	Atrophy 02/2015
1	Genomic Instability 10/2012
1	Chromosomal Instability (Chromosome Stability) 10/2012
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 08/2002
1	Androgen-Insensitivity Syndrome (Testicular Feminization) 01/2002

Drug/Important Bio-Agent (IBA)

25	polyglutamineIBA 01/2021 - 01/2002
22	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 01/2002
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2002
2	DNA (Deoxyribonucleic Acid)IBA 03/2015 - 10/2012
2	Nuclear Proteins (Protein, Nuclear)IBA 10/2012 - 11/2011
2	Hormones (Hormone)IBA 11/2011 - 07/2005
1	Deubiquitinating EnzymesIBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2015
1	bicalutamide (Casodex)FDA LinkGeneric 03/2015
1	enzalutamideIBA 03/2015
1	Androgen Antagonists (Antiandrogens)IBA 03/2015
1	Flutamide (Eulexin)FDA LinkGeneric 03/2015
1	Prostate-Specific Antigen (Semenogelase)IBA 03/2015
1	Staphylococcal Protein A (Protein A)IBA 10/2012
1	Testosterone (Sustanon)FDA Link 01/2012
1	Sirtuin 1IBA 11/2011
1	Glutamine (L-Glutamine)FDA Link 07/2003
1	LigandsIBA 12/2002
1	Molecular Chaperones (Chaperone, Molecular)IBA 03/2002

Therapy/Procedure

3	Therapeutics 10/2019 - 03/2015
1	Intraperitoneal Injections 03/2007
1	Castration 05/2004